My research focus is on improving clinical care related to nutritional status of children and health behaviors, particularly dietary, physical activity. I am also interested in prevention of chronic conditions from infancy onward. I have first-hand experience in the bi-directional processes of integrating research knowledge into clinical care and developing research questions based on clinical experience. I have past experience mentoring research of students and young investigators. I have participated in pediatric practice-based research through the Pediatric Practice Research Group (PPRG), a...

Walter Eppich, MD, PhD directs the Feinberg Academy of Medical Educators (FAME) and Faculty Development for the Department of Medical Education. He uses qualitative research methodologies to study the contribution of conversation to learning for individuals and teams. He has taught extensively on basic and advanced simulation educator courses and serves as principal faculty at the Harvard Center for Medical Simulation. Walter has been an invited speaker on topics related to feedback & debriefing around the world. He served on the Board of Directors of the Society for Simulation in Healthcare f...

My laboratory uses genetic mouse modeling tools to study Diffuse Intrinsic Pontine Glioma (DIPG), an incurable brain cancer that arises in children. Our three aims are to develop improved DIPG mouse models, to study the mechanism of novel oncogenes implicated in DIPG pathogenesis (e.g., H3K27M, ACVR1/ALK2), and to evaluate novel therapeutics

Cell and Molecular Immunology and Cardiovascular Disease.

The Sonic hedgehog signal in vertebrates is mediated by three C2H2 zinc finger transcription factors, GLI1, GLI2, and GLI3. We have shown that near identity of gene sequence exists between mouse and human GLI1 and that GLI1 functions as a transcription factor and that a critical domain in the COOH end of the protein is a transactivator with VP16-like structure. We established that GLI1 protein regulates a set of genes that coordinately control proliferation and may in part explain malignant transformation by misexpression of GLI1. We have established non-canonical activation of GLI1 by c-myc s...

I was born in San Francisco, California and grew up in the Bay Area. I obtained my bachelor's degree in Chemistry from Hillsdale College in Michigan, and my medical degree from the UC Davis School of Medicine. I completed my pediatrics residency and critical care fellowship at Children's Hospital Los Angeles. I practiced full time palliative care there for two years before moving to Chicago and joining the faculty at Feinberg, and now practice critical care and palliative care at Ann and Robert H. Lurie Children's Hospital.

Dr. Skibley is a pediatric hospitalist at Ann & Robert H. Lurie Children's Hospital of Chicago and Clinical Instructor, Pediatrics, at Northwestern University's Feinberg School of Medicine. She is board certified in pediatrics. Her clinical interests include breastfeeding medicine and the care of newborns with maternal chorioamnionitis. She splits her clinical time between the normal newborn nursery and the NICU and directs the nursery rotation for the pediatric residents. Dr. Skibley graduated from The University of Notre Dame and earned her medical degree from Southern Illinois University Sc...

Dr. Jerome Lane is an attending physician in Pediatric Nephrology at Lurie Children's Hospital of Chicago, and an Associate Professor of Pediatrics at the Northwestern University Feinberg School of Medicine. He earned a B.A. in Classics and Biology from Brandeis University in 1987, and his M.D. degree from the New York University School of Medicine in 1991. Dr. Lane completed his residency in Pediatrics at NYU Medical Center/Bellevue Hospital in 1994, and his fellowship in Pediatric Nephrology at the Albert Einstein College of Medicine/Montefiore Hospital in 1997.

I have had a long-standing interest in studying RNA regulatory mechanisms in development. My lab has focused on studying the mechanism of action of Evfs, novel long non-coding RNAs that regulate transcription factors essential for proper GABAergic interneuron development. Although a critical role for developmentally regulated transcription factors in patterning and differentiation has been established for some time, the role of long non-coding RNAs (lncRNAs) is only beginning to be understood. With genome-wide sequencing technologies, it is now known that the majority of transcripts are non-co...