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Northwestern University Feinberg School of Medicine
Department of Pediatrics

Critical Care Publications

Below are recent publications by faculty members in the Division of Critical Care in the Department of Pediatrics at Northwestern University Feinberg School of Medicine.

Recent PubMed Publications

  1. Liu B, Yi D, Li S, Ramirez K, Xia X, Cao Y, Zhao H, Tripathi A, Qiu S, Kala M  et al.  Single-Cell and Spatial Transcriptomics Identified Fatty Acid-Binding Proteins Controlling Endothelial Glycolytic and Arterial Programming in Pulmonary Hypertension.  Arterioscler Thromb Vasc Biol  2025 Jul;45(7):1145-1165. doi:10.1161/ATVBAHA.124.321173
  2. Sanchez-Pinto LN, Badke CM, Pololi L  Group Peer Mentoring: A Strategy to Promote Career Development and Improve Well-Being Among Early-Career Faculty in Pediatric Critical Care Medicine.  Pediatr Crit Care Med  2025 Jul 01;26(7):e952-e954. doi:10.1097/PCC.0000000000003763
  3. Farris RWD, Shah SS, Bennett TD, Brown SR, Cornell TT, Dziorny AC, Flynn A, Grunwell J, Heneghan JA, Kennedy CE  et al.  The PICU Data Collaborative: A Novel, Multi-Institutional, Pediatric Critical Care Dataset.  Pediatr Crit Care Med  2025 Jul 01;26(7):e941-e951. doi:10.1097/PCC.0000000000003758
  4. Lanziotti VS, Sanchez-Pinto LN  To: Closing the critical care knowledge gap: the importance of publications from low-income and middle-income countries.  Crit Care Sci  2025;37:e20250026. doi:10.62675/2965-2774.20250026
  5. McNerney KO, de Souza DC, Sanchez-Pinto LN  Consensus recommendations for early critical care management of paediatric HCT and IEC recipients: what comes next?  Lancet Child Adolesc Health  2025 Jun;9(6):363-365. doi:10.1016/S2352-4642(25)00129-4
  6. Martin B, Bennett TD, DeWitt PE, Russell S, Sanchez-Pinto LN  Use of the Area Under the Precision-Recall Curve to Evaluate Prediction Models of Rare Critical Illness Events.  Pediatr Crit Care Med  2025 Jun 01;26(6):e855-e859. doi:10.1097/PCC.0000000000003752
  7. Michelson KN, Fishman AC, Feinberg EC, Ross S, Wald HS, Auerbach C, Roth S  Antisemitism in American Healthcare: A Survey Study of Reported Experiences.  J Gen Intern Med  2025 Jun;40(8):1940-1943. doi:10.1007/s11606-024-09159-x
  8. Agha E, Sutter C, Ojewuyi I, Abramsohn EM, Andriano M, Bell C, Calix AL, Cherry JL, Downing K, Flower T  et al.  The Grief Navigation Trial: A multi-site pragmatic comparative effectiveness trial of two interventions to support parents after their child's unexpected or traumatic death.  Contemp Clin Trials  2025 May 26;155:107962. doi:10.1016/j.cct.2025.107962
  9. Copana-Olmos R, Casson-Rodriguez N, Diaz-Villalobos W, Urquieta-Clavel V, Tejerina-Ortiz M, Mendoza-Montoya C, Fernandez-Vidal M, Forest-Yepez M, Blanco-Espejo D, Rivera-Murguia I  et al.  Sepsis in Critically Ill Children in Bolivia: Multicenter Retrospective Evaluation of the Phoenix Criteria for Sepsis in a 2023 Cohort.  Pediatr Crit Care Med  2025 May 01;26(5):e699-e707. doi:10.1097/PCC.0000000000003714
  10. Badke CM, Wang A, Daniels LA, Sanchez-Pinto LN  Validation of Pediatric Sequential Organ Failure Assessment (pSOFA) Scores to Predict Critical Events in the Pediatric Intensive Care Unit.  J Intensive Care Med  2025 May;40(5):565-570. doi:10.1177/08850666241307630
  11. Zhang X, Yin X, Yap ML, Li Q, Huang L, Liu Y, Zhou B, Li Z, Zhao Y, Sun J  et al.  Effect of sodium-reduced potassium-enriched salt substitutes on stomach cancer: the Salt Substitute and Stroke Study (SSaSS).  BMC Med  2025 Apr 23;23(1):236. pii:236
  12. Zhang X, Brody JA, Graff M, Highland HM, Chami N, Xu H, Wang Z, Ferrier KR, Chittoor G, Josyula NS  et al.  Whole genome sequencing analysis of body mass index identifies novel African ancestry-specific risk allele.  Nat Commun  2025 Apr 11;16(1):3470. pii:3470
  13. Zhang X, Scadden AW, Marthi A, Buchanan VL, Qu Y, Ferrier KR, Chen BD, Graff M, Avila J, Boerwinkle E  et al.  Alterations in DNA Methylation, Proteomic, and Metabolomic Profiles in African Ancestry Populations with APOL1 Risk Alleles.  J Am Soc Nephrol  2025 Apr 07;. doi:10.1681/ASN.0000000688
  14. Campos MA, Riha IA, Zhang C, Mozes C, Scheidt KA, Zhang X  Discovery of DCAF16 Binders for Targeted Protein Degradation.  ACS Chem Biol  2025 Feb 21;20(2):479-488. doi:10.1021/acschembio.4c00799
  15. Riha IA, Campos MA, Jin X, Wang FY, Zhang C, Dunne SF, Cravatt BF, Zhang X  Exploiting the DCAF16-SPIN4 interaction to identify DCAF16 ligands for PROTAC development.  RSC Med Chem  2025 Feb 19;16(2):892-906. doi:10.1039/d4md00681j
  16. Badke CM, Carroll MS, Pendergrast TR, Weese-Mayer DE, Sanchez-Pinto LN  Assessing bedside measures of autonomic nervous system dysregulation in the PICU.  Pediatr Res  2025 Feb 06;. doi:10.1038/s41390-024-03778-0
  17. Sanchez-Pinto LN, Daniels LA, Atreya M, Faustino EVS, Farris RWD, Geva A, Khemani RG, Rogerson C, Shah SS, Weiss SL  et al.  Phoenix Sepsis Criteria in Critically Ill Children: Retrospective Validation Using a United States Nine-Center Dataset, 2012-2018.  Pediatr Crit Care Med  2025 Feb 01;26(2):e155-e165. doi:10.1097/PCC.0000000000003675
  18. Zhang C, Zhou C, Magassa A, Jin X, Fang D, Zhang X  A platform for mapping reactive cysteines within the immunopeptidome.  Nat Commun  2024 Nov 08;15(1):9698. pii:9698
  19. Asp RA, Paquette ET  Parent Perspectives on Social Risk Screening in the PICU.  Pediatr Crit Care Med  2024 Oct 01;25(10):953-958. doi:10.1097/PCC.0000000000003580
  20. Heneghan JA, Akande MY, Ramgopal S, Evans MD, Hallman M, Goodman DM  New Morbidities During Critical Illness and Associated Risk of ICU Readmission: Virtual Pediatric Systems Cohort, 2017-2020.  Pediatr Crit Care Med  2024 Oct 01;25(10):e405-e409. doi:10.1097/PCC.0000000000003542
  21. Zhang X, Duan S, Apostolou PE, Wu X, Watanabe J, Gallitto M, Barron T, Taylor KR, Woo PJ, Hua X  et al.  CHD2 Regulates Neuron-Glioma Interactions in Pediatric Glioma.  Cancer Discov  2024 Sep 04;14(9):1732-1754. doi:10.1158/2159-8290.CD-23-0012
  22. Setar L, Lee JG, Sanchez-Pinto LN, Coates BM  Accuracy and Interpretation of Transcutaneous Carbon Dioxide Monitoring in Critically Ill Children.  Pediatr Crit Care Med  2024 Sep 01;25(9):e372-e379. doi:10.1097/PCC.0000000000003564
  23. Sanchez-Pinto LN, Del Pilar Arias López M, Scott H, Gibbons K, Moor M, Watson RS, Wiens MO, Schlapbach LJ, Bennett TD  Digital solutions in paediatric sepsis: current state, challenges, and opportunities to improve care around the world.  Lancet Digit Health  2024 Sep;6(9):e651-e661. doi:10.1016/S2589-7500(24)00141-9
  24. Ashworth RC, Malone JR, Franklin D, Sorce LR, Clayman ML, Frader J, White DB, Michelson KN  Associations of Patient and Parent Characteristics With Parental Decision Regret in the PICU: A Secondary Analysis of the 2015-2017 Navigate Randomized Comparative Trial.  Pediatr Crit Care Med  2024 Sep 01;25(9):795-803. doi:10.1097/PCC.0000000000003534
  25. Liu B, Yi D, Xia X, Ramirez K, Zhao H, Cao Y, Tripathi A, Dong R, Gao A, Ding H  et al.  General Capillary Endothelial Cells Undergo Reprogramming Into Arterial Endothelial Cells in Pulmonary Hypertension Through HIF-2α/Notch4 Pathway.  Circulation  2024 Jul 30;150(5):414-417. doi:10.1161/CIRCULATIONAHA.123.067981
  26. Zhang X, Blackwell CK, Moore J, Liu SH, Liu C, Forrest CB, Ganiban J, Stroustrup A, Aschner JL, Trasande L  et al.  Associations between neighborhood characteristics and child well-being before and during the COVID-19 pandemic: A repeated cross-sectional study in the Environmental influences on Child Health Outcomes (ECHO) program.  Environ Res  2024 Jul 01;252(Pt 1):118765. doi:10.1016/j.envres.2024.118765
  27. Bennett TD, Argent AC, Sanchez-Pinto LN  Phoenix Criteria for Pediatric Sepsis and Septic Shock-Reply.  JAMA  2024 Jun 18;331(23):2050-2051. doi:10.1001/jama.2024.8202
  28. Atreya MR, Bennett TD, Geva A, Faustino EVS, Rogerson CM, Lutfi R, Cvijanovich NZ, Bigham MT, Nowak J, Schwarz AJ  et al.  Biomarker Assessment of a High-Risk, Data-Driven Pediatric Sepsis Phenotype Characterized by Persistent Hypoxemia, Encephalopathy, and Shock.  Pediatr Crit Care Med  2024 Jun 01;25(6):512-517. doi:10.1097/PCC.0000000000003499
  29. Zurawel AA, Coates BM  Time to split: biomarker trajectories in pediatric acute respiratory distress syndrome hint at underlying disease.  J Clin Invest  2024 May 15;134(10). pii:e180662
  30. Liu B, Yi D, Li S, Ramirez K, Xia X, Cao Y, Zhao H, Tripathi A, Qiu S, Kala M  et al.  Single-cell and Spatial Transcriptomics Identified Fatty Acid-binding Proteins Controlling Endothelial Glycolytic and Arterial Programming in Pulmonary Hypertension.  bioRxiv  2024 Apr 15;. pii:2024.02.11.579846
  31. Sanchez-Pinto LN, Bennett TD, DeWitt PE, Russell S, Rebull MN, Martin B, Akech S, Albers DJ, Alpern ER, Balamuth F  et al.  Development and Validation of the Phoenix Criteria for Pediatric Sepsis and Septic Shock.  JAMA  2024 Feb 27;331(8):675-686. doi:10.1001/jama.2024.0196
  32. Rissman L, Paquette ET  Family Challenges and Navigator Support: It is Time We Support Our Families Better.  Pediatr Crit Care Med  2024 Feb 01;25(2):180-182. doi:10.1097/PCC.0000000000003403
  33. Tager JB, Hinojosa JT, LiaBraaten BM, Balistreri KA, Aniciete D, Charleston E, Frader JE, White DB, Clayman ML, Sorce LR  et al.  Challenges of Families of Patients Hospitalized in the PICU: A Preplanned Secondary Analysis From the Navigate Dataset.  Pediatr Crit Care Med  2024 Feb 01;25(2):128-138. doi:10.1097/PCC.0000000000003385
  34. Walker SB, Winters JM, Schauer JM, Murphy P, Fawcett A, Sanchez-Pinto LN  Performance of Tools and Measures to Predict Fluid Responsiveness in Pediatric Shock and Critical Illness: A Systematic Review and Meta-Analysis.  Pediatr Crit Care Med  2024 Jan 01;25(1):24-36. doi:10.1097/PCC.0000000000003320
  35. Prigge AD, Coates BM  Can Airway Monocytes from Premature Infants Teach Us about Macrophage Differentiation in the Lungs?  Am J Respir Cell Mol Biol  2023 Dec;69(6):612-613. doi:10.1165/rcmb.2023-0305ED
  36. Rogerson CM, Abu-Sultaneh S, Loberger JM, Ross P, Khemani RG, Sanchez-Pinto LN  Predicting Duration of Invasive Mechanical Ventilation in the Pediatric ICU.  Respir Care  2023 Nov 25;68(12):1623-1630. doi:10.4187/respcare.11015
  37. Dai Z, Thorp EB  New Way to Study Pulmonary Hypertension in HFpEF.  Circ Res  2023 Nov 10;133(11):899-901. doi:10.1161/CIRCRESAHA.123.323753
  38. Wösten-van Asperen RM, la Roi-Teeuw HM, van Amstel RB, Bos LD, Tissing WJ, Jordan I, Dohna-Schwake C, Bottari G, Pappachan J, Crazzolara R  et al.  Distinct clinical phenotypes in paediatric cancer patients with sepsis are associated with different outcomes-an international multicentre retrospective study.  EClinicalMedicine  2023 Nov;65:102252. pii:102252
  39. Zhao Y, Li C, Zhang S, Cheng J, Liu Y, Han X, Wang Y, Wang Y  Inhaled nitric oxide: can it serve as a savior for COVID-19 and related respiratory and cardiovascular diseases?  Front Microbiol  2023;14:1277552. pii:1277552
  40. Sanchez-Pinto LN, Bhavani SV, Atreya MR, Sinha P  Leveraging Data Science and Novel Technologies to Develop and Implement Precision Medicine Strategies in Critical Care.  Crit Care Clin  2023 Oct;39(4):627-646. doi:10.1016/j.ccc.2023.03.002
  41. Machut KZ, Gilbart C, Murthy K, Michelson KN  A Qualitative Study of Nurses' Perspectives on Neonatologist Continuity of Care.  Adv Neonatal Care  2023 Oct 01;23(5):467-477. doi:10.1097/ANC.0000000000001096
  42. Sanchez-Pinto LN, Bennett TD, Stroup EK, Luo Y, Atreya M, Bubeck Wardenburg J, Chong G, Geva A, Faustino EVS, Farris RW  et al.  Derivation, Validation, and Clinical Relevance of a Pediatric Sepsis Phenotype With Persistent Hypoxemia, Encephalopathy, and Shock.  Pediatr Crit Care Med  2023 Oct 01;24(10):795-806. doi:10.1097/PCC.0000000000003292
  43. Zhou Z, Zhang Y, Tan C, Zhang J, Yi G, Wang B, Li Y, Lu H, Lu W, Zhang X  The long non-coding RNA BBOX1 antisense RNA 1 is upregulated in polycystic ovary syndrome (PCOS) and suppresses the role of microRNA-19b in the proliferation of ovarian granulose cells : Short title: BBOX1 antisense RNA 1 in cell proliferation.  BMC Womens Health  2023 Sep 21;23(1):508. pii:508
  44. Stephen RJ, Lucey K, Carroll MS, Hoge J, Maciorowski K, Jones RC, O'Connell M, Schwab C, Rojas J, Sanchez Pinto LN  Sepsis Prediction in Hospitalized Children: Clinical Decision Support Design and Deployment.  Hosp Pediatr  2023 Sep 01;13(9):751-759. doi:10.1542/hpeds.2023-007218
  45. Stephen RJ, Carroll MS, Hoge J, Maciorowski K, Jones RC, Lucey K, O'Connell M, Schwab C, Rojas J, Sanchez-Pinto LN  Sepsis Prediction in Hospitalized Children: Model Development and Validation.  Hosp Pediatr  2023 Sep 01;13(9):760-767. doi:10.1542/hpeds.2022-006964
  46. Zhang X, Brody JA, Graff M, Highland HM, Chami N, Xu H, Wang Z, Ferrier K, Chittoor G, Josyula NS  et al.  WHOLE GENOME SEQUENCING ANALYSIS OF BODY MASS INDEX IDENTIFIES NOVEL AFRICAN ANCESTRY-SPECIFIC RISK ALLELE.  medRxiv  2023 Aug 22;. pii:2023.08.21.23293271
  47. Atreya MR, Bennett TD, Geva A, Faustino EVS, Rogerson CM, Lutfi R, Cvijanovich NZ, Bigham MT, Nowak J, Schwarz AJ  et al.  External validation and biomarker assessment of a high-risk, data-driven pediatric sepsis phenotype characterized by persistent hypoxemia, encephalopathy, and shock.  Res Sq  2023 Aug 02;. pii:rs.3.rs-3216613
  48. Zhang X, Young C, Liao XH, Refetoff S, Torres M, Tomer Y, Stefan-Lifshitz M, Zhang H, Larkin D, Fang D  et al.  Perturbation of endoplasmic reticulum proteostasis triggers tissue injury in the thyroid gland.  JCI Insight  2023 Jun 22;8(12). pii:e169937
  49. Siddiqui MR, Reddy NM, Faridi HM, Shahid M, Shanley TP  Metformin alleviates lung-endothelial hyperpermeability by regulating cofilin-1/PP2AC pathway.  Front Pharmacol  2023;14:1211460. pii:1211460
  50. Zhao Y, Han X, Li C, Liu Y, Cheng J, Adhikari BK, Wang Y  COVID-19 and the cardiovascular system: a study of pathophysiology and interpopulation variability.  Front Microbiol  2023;14:1213111. pii:1213111

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