Focus of Work
As a pediatric and cardiac intensivist at Lurie Children’s hospital in Chicago, I am constantly challenged by patients with heart failure. Strategies to prom...[Read full text]Strategies to promote cell and tissue regeneration remain at the forefront of cardiovascular biology. We have developed a research program exploring the response of the stem cell compartment to two critical processes, aging and heart failure, to better understand the impact of epigenetic modifications driving these acquired phenotypes.
As a pediatric and cardiac intensivist at Lurie Children’s hospital in Chicago, I am constantly challenged by patients with heart failure. Strategies to promote cell and tissue regeneration remain at the forefront of cardiovascular biology. We have developed a research program to explore the epigenetics of stem cell aging, recognizing that atrial stem cells taken from younger patients are more robust than those taken from adults. We are also exploring the regulatory networks operative in end-stage heart failure through ventricular sampling and transcriptome analysis. This early work has been supported by benefactors support and regional foundations. Our work and tissue collection naturally led us to the development of a Cardiac Biorepository at Lurie Children’s, which has led to new developments across the Heart Center and the institution. Our work will ideally add to the regional presence for our Heart Center through the additional of bench research, and will providing an ongoing forum for our trainees to gain skills in basic and translational research. The Fontan Futures program at Lurie Children's connects infants with critical forms of congenital heart disease to clinical-grade biobanking services through the Mathews Center for Cellular Therapy; aiming to permit regenerative strategies for the failing heart in years to come.
Presently human cardiac tissues from our discarded biobank are supplied to collaborative investigators supporting discovery in direct fibroblast reprogramming, atrial tissue characterization, exploring pediatric cardiomyopathies via iPSC-CM differentiation, and understand the role of soluble MerTK in cardiac ischemia and recovery across the age spectrum.[Shorten text]
Select a keyword to see all related Feinberg faculty via the main faculty profile site.
Education and Certification
- MD: Johns Hopkins University (1997)
- Residency: University of Colorado Health Science Center, Pediatrics (2000)
- Fellowship: University of California Medical Center, San Francisco/Parnassus, Pediatrics Critical Care Medicine (2004)
- Board Certification: General Pediatrics, Pediatric Critical Care Medicine
Administrative office: 312-227-1551
Ann & Robert H. Lurie Children's Hospital of Chicago Box 73, Critical Care
225 E Chicago Avenue
Chicago IL 60611